Treatment of antiphospholipid syndrome

Health And Medical Video: The Antiphospholipid Syndrome - Dr. Michael Linenberger (October 2018).


Antiphospholipid syndrome without timely and purposeful treatment has a very poor prognosis. Especially this disease is dangerous during pregnancy - both for the mother and for the fetus.

During the antiphospholipid syndrome antibodies are formed to their own phospholipids of the cell.

Emerged complexes violate the work of platelets - contribute to their gluing, which leads to thickening of the blood, slowing the bleeding, the formation of blood clots, clogging of vessels, damage to the organs and tissues, there are numerous heart attacks and strokes of the affected organs.

This condition is especially dangerous for pregnant women, since the antiphospholipid syndrome is often the cause of fetal death.

Treatment of antiphospholipid syndrome

When confirmed diagnosis of antiphospholipid syndrome should follow several general recommendations for the regime:

  • Avoid prolonged sitting or standing (real estate contributes to thrombosis);
  • Women should not use oral contraceptives;
  • You should not engage in traumatic sports.

Treatment of antiphospholipid syndrome is aimed at:

  • Improvement of blood flow (prevention of thrombosis);
  • Decrease in autoimmune activity (especially during pregnancy planning and its course to prevent miscarriages).

Medicinal treatment

  1. Indirect anticoagulants (eg warfarin) and antiplatelet agents (for example, aspirin) are drugs that reduce blood coagulation and improve its fluidity, thereby reducing the risk of thrombus formation. With already occurring thrombosis and complications directly related to it, it is advisable to appoint a direct anticoagulant (heparin, etc.). However, their appointment is not always possible, because such drugs have multiple contraindications. They absolutely can not be used by pregnant women and people suffering from peptic ulcer. With extreme caution and only by the appointment of a doctor, anticoagulants can be taken by people with diseases of the liver or kidneys.

  2. Glucocorticoids and cytostatics are used when necessary to suppress autoimmune activity. This is necessary if the patient has an autoimmune disease (systemic lupus erythematosus, rheumatism, etc.) in the history, but most often it is relevant for pregnant women. This treatment helps to prevent miscarriage and normalize the blood flow of the placenta that feeds the fetus.
  3. Against the background of suppression of immune activity, it is advisable to appoint immunomodulators to prevent the activation of a viral infection. Often, human immunoglobulin is used for this purpose.
  4. Methods of extracorporal hemocorrection (thermoplasm sorption, cascade filtration of plasma, etc.) - modern methods of blood purification, which allow to remove or significantly reduce the content of antiphospholipid antibodies in the blood and factors that activate the blood coagulation system, thereby giving a greater guarantee of the prevention of thrombosis.

Treatment of a patient with antiphospholipid syndrome should be selected and under strict supervision of the doctor and frequent control of laboratory parameters of blood coagulation. In any case, such a patient should receive treatment for life.

Treatment of antiphospholipid syndrome
Category Of Medical Issues: Diseases