The new remedy in principle "forbids" the brain to perceive the pain and can greatly help with cancer, back injuries and other ailments when the pain is tormented for years.
Specialists from McGill University in Canada have found drugs that are able to completely replace morphine and other severe opiate drugs for pain caused by cancer, internal inflammation and nerve damage. A new class of analgesics can "calm down" pain that persists for many months or even years.
Approximately 7-8% of the world's population suffers from such pains, and in every twentieth they become unbearable. As a rule, in order to get rid of such pain ordinary analgesics do not help, and people use opioid analgesics. Unfortunately, this leads to addiction, generates serious side effects. In addition, the lack of opiates further increases pain and even leads to death.
In the process of finding an effective substitute for drugs, the attention of scientists attracted the well-known hormone melatonin, which has long been sold in pharmacies, which perfectly relieves depressive phenomena, leads the body to rest and is a wonderful sleeping pill. By all indications, melatonin should be a great pain reliever. However, no properties of analgesics have a pharmaceutical drug on its basis, with the fact that melatonin affects several types of brain receptors that are responsible for regulating sleep, reduce depression and stabilize circadian rhythms and relieve pain.
As it turned out later, the main problem was that synthetic melatonin activates two types of receptors, MT1 and MT2, which simultaneously produce contradictory and opposite effects. That is, the two different systems perfectly cooperate in depression, loss of sleep, but also "quench" each other's work, if necessary, to turn off pain.
The team led by Dr. Associate Professor of the Department of Psychiatry at the Faculty of Medicine McGill Gabriella Gobbi, isolated from a synthetic melatonin substance that acts only on the receptor MT2, without affecting other receptors. In the studies, scientists have tried to find out how the stimulation of this receptor is displayed on the patient's sleep.
Experimenting with different doses, they found that in large doses, the drug really works like a hypnotic, but in small ones - completely removes even the most severe neuropathic pain. As shown by the study, the activation of low doses of MT2 receptors, not only blocks the nerve signal, but completely disables the brain's neurons that respond to pain. That is, the brain does not accept any pain stimuli - it's more "not interesting".
This component of melatonin has already been proposed as a new class of pain medications without side effects. In large doses it will be used in the evenings as sleeping pills, and in the daytime will replace opiate medications. So now you can completely get rid of the pain and the associated insomnia without any harm to your health.