Long before the onset of the first symptoms of Alzheimer's disease in humans, a marked decrease in body weight begins.
It is believed that increased body weight in middle age is a risk factor for Alzheimer's, but in a recent study it was shown that increased body weight in old age almost never combined with this type of dementia.
Losing weight is one of the earliest symptoms of Alzheimer's appear long before memory loss.
In particular, according to researcher Jeffrey M. Burns of the Alzheimer's Research Center University of Kansas (USA), among older people without any clinical manifestations of Alzheimer normal body weight or decrease (BMI below 25) combined with the detection of certain structures A brain that is the first sign of the disease.
The study included only those patients who have no memory disorders to rule out the likelihood of weight loss as a result of the consequences of the disease when a person forgets to eat.
Scientists believe that weight loss may be an early manifestation of the disease. "We tend to think that Alzheimer's disease - a disease of the brain. However, it may be that this is not true and this pathology is systemic," - says Jeffrey M. Burns.
Relationship between Alzheimer's Disease and BMI
Prior to this study, Burns and co-authors have shown that Alzheimer's Disease is combined with a decrease in bone density and loss of muscle mass, which also appear long before memory loss.
One of the latest studies published in the journal Neurology was attended by 506 people, without any clinical manifestations of memory decline, with a slight memory loss and a verified diagnosis of Alzheimer's.
To find the morphological markers of Alzheimer's disease, all participants had MRI of the brain.
The fact is that with this pathology in the brain certain structures are detected - the β-amyloid plaques, which may also be the cause of memory loss.
It has been shown that 85% of participants with normal or reduced body weight, even without any clinical manifestations of the disease, detect amyloid plaques in the brain. Among those with a high body weight, this figure was only 48%.
Inaccuracy of the study
Many scholars doubt the demonstration of this study. The fact is that there are no indications of who was part of a group with a reduced body weight: whether these people always had asthenics or body weight loss occurred in the elderly.
In addition, considering the age of patients, there are many causes that could lead to weight loss, in addition to Alzheimer's. Therefore, informational body weight for further development of Alzheimer's disease should not be exaggerated, although weight loss in the elderly should in any case be alarmed.
Further research is needed to confirm or refute the results. Perhaps the explanation of the data obtained will finally help to unravel the pathogenesis of Alzheimer's disease.