Immunodeficiency states

Health And Medical Video: Usmle Immunology Part 8 I Immunodeficiency Disorders (April 2019).


What is immunity and immunodeficiency.

The word "immunity" has long become commonplace not only for doctors, but also people not related to medicine: we often have to hear it in various commercials, transfers on environmental protection, etc.

Indeed, dynamic changes in the parameters of the immune system occur in response to various states of the body: infections, injuries, tumors. Is it a pathology? In most cases, no, it is a normal reaction of a living organism. After all, the main function of the immune system - is the fight with all alien, be it a bacterium or a tumor cell.

However, in some cases, changes in the immune system are long-term, pathological, such states are called immunodeficiency (IRS). Depending on the causes of the occurrence, they are divided into primary and secondary.

Secondary IUDs are the result of serious external influences on the body: radiation, immunosuppressive chemotherapy, severe infections (eg, HIV). Compared to the first group, they occur much more often, however, as a rule, they represent less diagnostic problems, as they are the result of already known factors. On the contrary, the primary immunodeficiency states are characterized by pronounced hypodiagnosis. Often, patients with primary IUD do not survive to an adequate diagnosis. In this regard, in this issue the main place is precisely the primary violations of immunity.

In addition, the manifestations and tactics of secondary IUD therapy are largely similar to those with primary IRS. In most cases, the primary both in the primary and secondary immunodeficiencies is an infectious syndrome. However, it is important to remember that the violation of the main function of the immune system - the recognition of its and others - leads to an increased frequency of autoimmune, tumorous and less - allergic diseases in patients with IRS. In addition, defects in immunity may be accompanied by excessive lymphoproliferation and a violation of control of inflammation. Some of the private aspects of immunodeficiency states are devoted to several articles of this issue.

Primary immunodeficiency states (PIDs) are a group of severe genetically determined diseases caused by a violation of one or more immune defense mechanisms. Most of these conditions debuted in early childhood with increased susceptibility to infectious diseases.

Currently more than 100 forms of BID are described. The frequency of primary immunodeficiency births ranges from 1: 10,000 people. Early diagnosis and adequate therapy for BPH can achieve a stable overall state of patients with most of these diseases. However, due to the low alertness of pediatricians and general practitioners in relation to primary immunodeficiency, there is an unjustifiably high disability and mortality of patients with BPH due to infectious and other complications.

Magazine "Hard patient" №2-2007.

The article is provided by the charity fund of assistance to children with immunity "Sunflower".

Immunodeficiency states
Category Of Medical Issues: Diseases