Scientists at the Harvard Institute of Cancer and Medical School found that cancerous cancers play an important role in a healthy body. Being in the brain cells, it regulates memory processes and may be associated with the development of Alzheimer's disease.
Cyclin E is one of the proteins responsible for the development of various tumors and blood cancer. However, a new study found that it also plays a decisive role in the formation of neural bonds (synapses) in the brain.
This protein virtually leads to double life: its hyperproduction is detected in many types of cancer, but at the same time, its level is high and in normal brain cells. Moreover, scientists have found that cyclin E is necessary for memory.
Cycles and cancer
Cycles are the key enzymes in the process of regulating the cell cycle and are normally found in the cells that are in the distribution stage. They control the transition of cells from one stage of life cycle to another.
Hyperproduction of cyclin E causes an accelerated cell division, allowing tumor cells to grow and spread throughout the body, leading to the development of several types of cancers, including breast, ovarian, colon and blood cancer.
Cyclin E and memory
Despite the fact that mainly cyclin E is found in split cells, about ten years ago, scientists discovered the same protein in the formed nerve cells. What functions he performs there for a long time remained unknown.
However, a recent study has shown that cyclin E in neurons binds to the Cdk5 enzyme, which leads to an increase in the number of nerve synapses and, thus, to improved memory.
Scientists have tested their theory in experiments on laboratory animals. A standard memorization and learning training was conducted in mice in which mice, swimming in the water, had to find a platform on which they could rest and remember its position in the following tests. Then the platform moved, forcing the mice to "forget" about her position, to learn and remember the new one.
As expected, mice with a lack of cyclone E coped worse with mice with normal protein levels. This experiment confirmed the importance of cyclone E for learning and memorizing processes.
Cyclin E and Alzheimer's Disease
Researchers have identified the potential relationship of cyclin E to the development of Alzheimer's disease, since this protein binds to the cyclin-dependent Cdk5 kinase involved in memory processes.
Hyperactivity Cdk5 is manifested in Alzheimer's disease, and blocking this enzyme leads to a reduction in the symptoms of the disease in animals.
Cyclin E binds to the molecule Cdk5, blocking its activity. Experiments in mice have shown that the lower the level of cyclin E in the cells of the brain, the less synapse is formed and the more memory suffering in animals.
Thus, regulation of the level of cyclin E can be another way of alleviating the symptoms of Alzheimer's disease.
The results of the study are published in the Developmental Cell.