The fibers of the fibrin are able to stretch perfectly, making the blood clot extremely resistant to blood flow.
Fibrin is a macromolecular protein that forms the structural basis of the thrombus, that is, the blood clot. Normally, a thrombus is formed to stop bleeding when cuts, injuries or after surgery.
Synthesis of fibrin is a complex and multistage process in which a host of enzymes and other biologically active compounds is involved.
Lack of fibrin in the body leads to bleeding and hemorrhages and occurs in various congenital diseases (for example, liver) or acquired states (massive blood loss, sepsis or DVS syndrome).
Excess fibrin promotes thrombosis, that is, the pathological formation of blood clots in different vessels, including the heart, brain and extremities.
Recent studies by scientists from the University of Wake Forest (USA) have shown that fibrin fibers possess unique stretching capabilities that outweigh the properties of many natural substances.
It is the extremely high fibrin tension that helps the blood flow to stay in the vessel, where it is affected by the huge force of blood flow that seeks to remove the blood clot.
Scientists conducted a series of laboratory experiments with fibrin, trying to stretch its fibers as much as possible.
It turned out that the fibrin is capable of stretching three times the length of its own fiber, completely retaining the shape of the molecules after returning to its original state.
In some cases, before breaking, the fibers stretched to six. The obtained indicators exceed the ability to stretch all known biological materials, including the web.
It is the flexibility of fibrin that determines the stability of blood clot in the vessel and the stopping of bleeding. Due to the fibrin, the thrombus acquires excellent elasticity, elasticity and resistance to the effects of blood flow.
However, under adverse conditions, such as atherosclerosis or predisposition to thrombosis, similar properties of fibrin become negative for the body.
The results of the study help to understand how difficult it is to remove blood clots from the blood vessels of the heart and brain, where they violate normal blood flow and, ultimately, contribute to the development of a heart attack or stroke.
The results of laboratory experiments by American scientists are published in the scientific journal Science.