Articular chondrocalcinosis: causes and symptoms

What Causes Osteoarthritis Joint Disease? - Manipal Hospital (Health And Medical Video 2017).

Chondrocalcinosis - a chronic, slowly progressive disease, caused by the deposition of microcrystals of calcium salts in the articular cartilage and around the articular tissues.

Pathology occurs predominantly in 55-60 years, with the same frequency in men and women. The manifestations of the disease are in many respects similar to gout.

The main factors influencing the development of chondrocalcinosis:

  • Hereditary predisposition.
  • Often pseudopodagra develops in patients with hemophilia and hemochromatosis, anemia and other diseases associated with a violation of iron metabolism in the body (deposition of hemosiderin contributes to the development of chondrocalcinosis).
  • Diseases that lead to disturbances in the metabolism of calcium and inorganic pyrophosphate (primary hyperparathyroidism, amyloidosis, hypothyroidism, etc.).
  • Conditions causing degenerative changes in cartilage tissue (rheumatoid polyarthritis, age-related arthrosis, etc.).

Development of chondrocalcinosis

Normally, pyrophosphate is an intermediate exchange product when cartilage collagen is synthesized. It is formed by cartilage cells by chondrocytes, but subsequently destroyed under the influence of tissue enzyme pyrophosphatase.

For a number of diseases there is a decrease in the activity of this enzyme, for example, with increased content in the tissues of copper or iron, so the salt of calcium pyrophosphate is first deposited at the depth of the articular cartilage, then on its surface, and then in the synovial membrane and around the arterial tissues.

Periods of intense accumulation of pyrophosphate crystals in the intra-articular (synovial) fluid and synovial membrane lead to exacerbations of arthritis (attacks or attacks), accompanied by severe edema and pain in the joints.

The main manifestations of chondrocalcinosis

Acute attack of chondrocalcinosis usually develops within one or two days, manifested by severe pains and edema of the joint, reddening of the skin over it and limiting the volume of movements. However, unlike gout, knee joints are more commonly affected, and several joints, including the upper limbs, are involved in the process.

Often an attack accompanied by a fever and a general malaise, inflammatory changes can last from one week to one and a half months, but pass at the beginning of the disease without a trace.

Attacks can be repeated in a few weeks or several years. Subsequently, the frequency of attacks increases, the process involves an increasing number of joints, sometimes in the process not all patients are involved joints - the migratory nature of pain.

After stihinija exacerbations of a patient can continue to disturb joint pains, sometimes its small puffiness remains. Subsequently, the volume of movements gradually decreases, joints deform.

In some cases, the spine is involved in the process, then the patient appears pains that resemble radiculitis manifestations, leading to a decrease in mobility in one or another department of the spine. In the later stages of the disease, the circumcirculatory tissue and tendons participate in the process.

Hereditary chondrocalcinosis often occurs up to 30 years and proceeds with the involvement of several joints, including small joints of the brushes and the spine, accompanied by pronounced clinical manifestations and common, progressive calcinosis, which leads to limitation of the spine mobility due to the grafting of its forward longitudinal ligament - ossifying Ligamentosis

Articular chondrocalcinosis: causes and symptoms

Category Of Medical Issues: Diseases